Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
Fully refundableReserve now, pay when you stay
$229 nightly
The price is $251 total per night from Aug 2 to Aug 3
$251 total
Aug 2 - Aug 3
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"Very clean"
Reviewed on Jul 29, 2026
The Shepherd Hotel Downtown Clemson
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
$183 nightly
The price is $203 total per night from Aug 2 to Aug 3
$203 total
Aug 2 - Aug 3
Total with taxes and fees
A restaurant and a bar/lounge are featured at this hotel. WiFi in public areas is free. Valet parking, a lobby fireplace, and luggage storage are also ...
"First time here. Fantastic. Heart of downtown Clemson, walk to campus. Amenities were excellent and staff was extremely helpful and knowledgeable."
Reviewed on Jul 30, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$361 nightly
The price is $396 total per night from Aug 19 to Aug 20
$396 total
Aug 19 - Aug 20
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Great location and decor."
Reviewed on Jul 29, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
Fully refundableReserve now, pay when you stay
$157 nightly
The price is $172 total per night from Aug 9 to Aug 10
$172 total
Aug 9 - Aug 10
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Nice location within walking distance to many restaurants and shopping. Clean room. Some construction in the lobby area."
Reviewed on Jul 26, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$85 nightly
The price is $93 total per night from Aug 2 to Aug 3
$93 total
Aug 2 - Aug 3
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Great experience"
Reviewed on Jul 29, 2026
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
Fully refundableReserve now, pay when you stay
$105 nightly
The price is $117 total per night from Aug 16 to Aug 17
$117 total
Aug 16 - Aug 17
Total with taxes and fees
This hotel features a 24-hour gym and a seasonal outdoor pool. Traveling on business? Take advantage of the 24-hour business center and free WiFi in public areas. ...
"Bathroom could have been a lot cleaner, and the showerhead spewed water like a fire hose making it nearly impossible to keep the floor dry. Our room was directly in front of the breakfast area which left us with zero privacy."
Reviewed on Jul 30, 2026
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $103 total per night from Aug 2 to Aug 3
$103 total
Aug 2 - Aug 3
Total with taxes and fees
This hotel features a gym and a seasonal outdoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Guests will ...
Hyatt Place Greenville Downtown
128 East Broad Street Greenville SC
Fully refundableReserve now, pay when you stay
$139 nightly
The price is $153 total per night from Aug 9 to Aug 10
$153 total
Aug 9 - Aug 10
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $94 total per night from Aug 6 to Aug 7
$94 total
Aug 6 - Aug 7
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
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See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd Anderson SC
$72 nightly
The price is $80 total per night from Aug 6 to Aug 7
$80 total
Aug 6 - Aug 7
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
32 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
The Shepherd Hotel Downtown Clemson
5 out of 5
Posted 3 hours ago
Travelocity Verified Review
"First time here. Fantastic. Heart of downtown Clemson, walk to campus. Amenities were excellent and staff was extremely helpful and knowledgeable."
A verified traveler stayed at The Shepherd Hotel Downtown Clemson
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