Book Hotels in Upstate South Carolina, SC
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Top Upstate South Carolina hotels
Hotel Hartness
120 Halston Avenue Greenville SC
$219 nightly
The price is $241 total per night from Jun 21 to Jun 22
$241 total
Jun 21 - Jun 22
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Enjoy the seasonal outdoor pool and perks like free self parking. ...
"This was a home large home at one point they added on additional wing. It’s southern country charm boutique hotel in the neighborhood of an up and coming expensive housing development"
Reviewed on Jun 7, 2026
Grand Bohemian Lodge Greenville, Autograph Collection
44 EAST CAMPERDOWN WAY Greenville SC
Fully refundableReserve now, pay when you stay
$249 nightly
The price is $273 total per night from Jul 5 to Jul 6
$273 total
Jul 5 - Jul 6
Total with taxes and fees
A full-service spa, a 24-hour gym, and a restaurant are all featured at this smoke-free hotel. Traveling on business? Take advantage of the business center, ...
"Great room in a beautiful facility!"
Reviewed on Jun 5, 2026
Drury Inn & Suites Greenville
10 Carolina Point Pkwy Greenville SC
Fully refundableReserve now, pay when you stay
$119 nightly
The price is $131 total per night from Jun 21 to Jun 22
$131 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features an outdoor pool and an indoor pool. Traveling on business? Take advantage of the business center and free WiFi in public areas. Enjoy the ...
"I know it is becoming the trend at businesses, for the majority of the staff to be unfriendly. However, friendliness & saying "Hello" at the very least is not a difficult thing for anyone. I come from decades of skilled customer service, and majority friendliness amongst staff should be standard ..."
Reviewed on Jun 13, 2026
Hyatt Place Greenville Downtown
128 East Broad Street Greenville SC
Fully refundableReserve now, pay when you stay
$143 nightly
The price is $158 total per night from Jun 21 to Jun 22
$158 total
Jun 21 - Jun 22
Total with taxes and fees
This hotel features a restaurant, an indoor pool, and a bar/lounge. Traveling on business? Take advantage of the 24-hour business center, free WiFi in public ...
"I was staying in the room alone and the staff accidentally assigned him to my room where I was sleeping and scared me and him to death. It could have been a dangerous situation and they said they would comp my stay, but they only comped one night."
Reviewed on Jun 13, 2026
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Jun 28 to Jun 29
$121 total
Jun 28 - Jun 29
Total with taxes and fees
A golf course, a 24-hour gym, and a restaurant are all featured at this resort. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"We were in town for a family wedding. The hotel was perfect. We had a suite for the 4 of us, and we had plenty of room to get ready for the wedding. Happy hour was nice as well."
Reviewed on Jun 13, 2026
Hyatt Regency Greenville
220 N Main St Greenville SC
$157 nightly
The price is $172 total per night from Jul 1 to Jul 2
$172 total
Jul 1 - Jul 2
Total with taxes and fees
This smoke-free hotel features 2 restaurants, a bar/lounge, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"The location is great! The room was nice and spacious. I would stay here again"
Reviewed on Jun 13, 2026
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
851 Congaree Rd Greenville SC
Fully refundable
$99 nightly
The price is $109 total per night from Jul 12 to Jul 13
$109 total
Jul 12 - Jul 13
Total with taxes and fees
This smoke-free hotel includes 2 restaurants, an indoor pool, and a 24-hour gym. Traveling on business? Take advantage of the 24-hour business center, free WiFi ...
"Good"
Reviewed on Jun 13, 2026
Hilton Greenville
45 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $121 total per night from Jun 29 to Jun 30
$121 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the 18 conference rooms, free WiFi in public areas, ...
"Great place to stay. It’s in a great part of town. Very clean and safe."
Reviewed on Jun 13, 2026
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr Greenville SC
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $102 total per night from Jun 29 to Jun 30
$102 total
Jun 29 - Jun 30
Total with taxes and fees
This hotel features a restaurant, a 24-hour gym, and a bar/lounge. Traveling on business? Take advantage of the business center and free WiFi in public areas. ...
"Great place to stay. It is prohibited to smoke or vape which is great but, they allow pets. We found doggy waste in the hallway on the 6th floor and it smelled horrible."
Reviewed on Jun 13, 2026
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See all available properties in Upstate South Carolina
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Cheap Upstate South Carolina hotels
Baymont by Wyndham Anderson Clemson
128 Interstate Blvd Anderson SC
$64 nightly
The price is $71 total per night from Jul 12 to Jul 13
$71 total
Jul 12 - Jul 13
Total with taxes and fees
7/10 Good! (889 reviews)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels in Upstate South Carolina with star-rating
Check Upstate South Carolina Hotels by Star Rating
4 Star Hotels
32 properties
Recent Upstate South Carolina hotel reviews by fellow wanderers
Best Western Plus Greenville I-385 Inn & Suites
5 out of 5
Posted less than an hour ago
Travelocity Verified Review
"The entire staff was awesome! The breakfast was incredible. I would highly recommend this hotel to anyone traveling on the area!!"
A verified traveler stayed at Best Western Plus Greenville I-385 Inn & Suites
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